Cancer Genomics
Recent technological advances have, for the first time, permitted the interrogation of gene copy number, allele specificity, transcription factor binding, transcript changes and chromatin structure on a whole-genome level.
These significant advances in molecular and biochemical tools and their applications to cancer biology are starting to reveal a novel taxonomy of cancers and provide functional insights into gene regulation, cellular pathways, and tissue organization.
Cancer genomics uses the power of these tools to understand the processes driving malignant transformation and progression.
Scientists at CRI have significant expertise in a diversity of cancer genomic areas including molecular classification of human and model organism cancers, mechanisms of drug resistance, novel therapeutic target discovery and validation, cancer stem cells, and mechanisms of gene regulation at the chromatin level.
Genomics research at the Institute is complemented by expertise in the Core Genomics Facility.
Group Leaders in this area are:
